Faculty Directory

Donald T. Miller


Donald T. Miller

OP 512


The Miller Lab on Advanced Ophthalmic Imaging.

  • Ph.D.–(University of Rochester)
Courses Taught
  • V 501/2  Integrative Optometry (Problem Based Learning)
  • V 521/3  Geometrical and Visual Optics I & II
  • V 711       Introduction to Vision Sciences: Optics of the Eye
  • SC932    Ophthalmic Adaptive Optics (SPIE short course)

Dr. Miller earned a B.S. in applied physics from Xavier University (1988) and a Ph.D. in optics from University of Rochester (1996). Most of his doctoral work was conducted at the Center for Visual Science, where he developed a high-resolution retina camera that captured the first images of individual photoreceptor cells in the living human eye.  As a postdoctoral fellow at Rochester, he was instrumental in the development of the first adaptive optics instrument for correction of ocular aberrations. This was followed by a National Research Council Research Associate position at Wright-Patterson Air Force Base in Dayton, Ohio. He joined the faculty at Indiana University School of Optometry in 1998 and currently holds the rank of Professor.   

At Indiana, Dr. Miller splits his time between teaching optics to professional and graduate students and conducting research on the optical properties of the eye. He has received the Trustees’ Teaching Award twice for excellence in teaching. He is a founding member of the Center for Adaptive Optics, a consortium of university, government and industry researchers funded for 10 years by the NSF. He was also a member of a NIH Bioengineering Research Partnership hosted at the University of California, Davis. The partnership received a R&D 100 Award for its development of a MEMS-based Adaptive Optics Optical Coherence Tomography instrument. He is a recipient of multiple NIH-R01 grants. Dr. Miller is actively involved in numerous vision and eye-related professional societies, acting as a reviewer and guest editor for journals, an invited speaker and a member of program organizing committees. He has twice chaired the OSA Adaptive Optics Topical Meeting and regularly serves on the program committee of the SPIE Ophthalmic Technologies Conference. He is a Fellow of the Optical Society of America. 

  • Liu Z, Kocaoglu OP, Miller DT, “In-the-plane design of an off-axis ophthalmic adaptive optics system using toroidal mirrors,” Biomed. Opt. Express 4, 3007-30 (2013).
  • Cense B, Wang Q, Lee S, Zhao L, Elsner AE, Hitzenberger CK, Miller DT, “Henle fiber layer phase retardation measured with polarization-sensitive optical coherence tomography,” Biomed. Opt. Express 4, 2296-306 (2013).
  • Jonnal RS, Kocaoglu OP, Wang Q, Lee S, Miller DT, “Phase-sensitive imaging of the outer retina using optical coherence tomography and adaptive optics,”  Biomed. Opt. Express 3, 104-124 (2012).
  • Kocaoglu OP, Cense B, Jonnal RS, Wang Q, Lee S, Gao W, Miller DT, “Imaging retinal nerve fiber bundles using optical coherence tomography with adaptive optics,” Vis. Research 51, 1835-1844 (2011).
  • Kocaoglu OP, Lee S, Jonnal RS, Wang Q, Herde AE, Derby JC, Gao W, Miller DT, "Imaging cone photoreceptors in three dimensions and in time using ultrahigh resolution optical coherence tomography with adaptive optics," Biomed. Opt. Express 2, 748-763 (2011).
  • Miller DT, Kocaoglu OP, Wang Q, Lee S, "Adaptive optics and the eye (super resolution OCT)," Eye 25, 321-330 (2011).
  • Wang Q, Kocaoglu OP, Cense B, Bruestle J, Jonnal RS, Gao W, Miller DT, "Imaging Retinal Capillaries Using Ultrahigh-Resolution Optical Coherence Tomography and Adaptive Optics", Invest. Ophthalmol. Vis. Sci. 52, 6292-9 (2011).
  • Jonnal RS, Besecker JR, Derby JC, Kocaoglu OP, Cense B, Gao W, Wang Q, Miller DT, “Imaging outer segment renewal in living human cone photoreceptors,” Opt. Express 18, 5257-5270 (2010).
  • Gao W, Jonnal RS, Cense B, Kocaoglu OP, Wang Q, Miller DT, "Measuring directionality of the retinal reflection with a Shack-Hartmann wavefront sensor," Opt. Express 17, 23085-23097 (2009).
  • Cense B, Gao W, Brown JM, Jones SM, Jonnal RS, Mujat M, Park BH, de Boer JF, Miller DT, “Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics,” Opt. Express 17, 21634-21651 (2009).
  • Cense B, Koperda E, Brown JM, Kocaoglu OP, Gao W, Jonnal RS, Miller DT, "Volumetric retinal imaging with ultrahigh-resolution spectral-domain optical coherence tomography and adaptive optics using two broadband light sources," Opt. Express 17, 4095-4111 (2009).
  • Miller DT and Roorda A, Adaptive optics in retinal microscopy and vision, Chapter 17 in Handbook of Optics, 3rd Edition Vol. III: Vision and Vision Optics, eds. Bass M, Decusatis C, Enoch JM, Lakshminarayanan V, Li G, Macdonald C, Mahajan VN, Van Stryland E, McGraw-Hill, New York, (2009).


  • Miller DT, Jonnal RS, Qu J, Thorn KE. Method and apparatus for improving both lateral and axial resolution in ophthalmoscopy. U.S. Patent #7,364,296.
  • Cense AJ, Miller DT. Devices and methods for polarization-sensitive optical coherence tomography with adaptive optics. PCT/US2010/021759.

Dr Miller’s group develops and uses high-resolution optical systems to image structures in the retina that are too minute to be seen with clinical instruments. By tracking structural changes over time, they are able to reconstruct physiological processes actively occurring in the retina at the cellular level. This capability to observe “living histology” not only empowers scientists to study vision at the most fundamental level, but may also enable eye care specialists to detect morphological and/or physiological changes at the onset of retinal pathology. This may be particularly beneficial for early diagnosis and treatment of leading causes of blindness such as age-related macular degeneration, glaucoma, and diabetic retinopathy.

For more information please visit The Miller Lab on Advanced Ophthalmic Imaging.


Figure. High-resolution volume images of the retina reveal (A) individual retinal nerve fiber bundles, (B) the tiniest of retinal capillaries and (C) mosaics of individual cone photoreceptors in patients. Images were acquired with the AO-OCT ophthalmoscope developed in Miller’s lab.

Funding Sources

  1. National Eye Institute, R01 EY018339, Optical Imaging of the Photoreceptor-RPE Complex
  2. National Eye Institute, R01 EY014743, Ophthalmic Imaging Using Adaptive Optics and OCT, (John Werner, PI)
  3. Indiana University Collaborative Research Grant